Answer
An example of gene mutation is
sickle-cell anaemia, where there is substitution of a base thymine by
adenine.in the gene that codes for the
beta polupeptide chain. Sickle-cell anaemia patients have abnormal haemoglobin
molecules with valine instead of glutamic acid as the sixth amino acid for both
the beta-polypeptide chains.
A
sickle-cell haemoglobin easily crystallize at low concentrations of oxygen and
the red blood cells are pilled into a sickle shape. These sickle red blood cell
can easily break and clump together to clog the blood capillaries, impeding the
flow of blood. This results in less oxygen is transported to the muscles and
the internal organs. Sickle-cell patients usually suffer from heart problem,
kidney failure, abdominal pains, paralysis and premature death.
Assignment submitted by L.Y., Kong, S. H., Lim, S. C., Soo, C. W.
No comments:
Post a Comment