Answer
- Lipid Synthesis
- Fatty acid synthesis is catalyzed by fatty acid synthetase using the substrates acetyl-CoA and malonyl-CoA, the reductant NADPH, and a small protein called acyl carrier protein, which carries the growing fatty acid chain; the fatty acid is lengthened by adding two carbons at a time to its carboxyl end
- Triacylglycerols are formed from the reduction of dihydroxyacetone phosphate (a glycolytic pathway intermediate) to glycerol 3-phosphate, which then undergoes esterification with two fatty acids to form phosphatidic acid; this can then be used to produce triacylglycerol
- Phospholipids are also produced from phosphatidic acid using a cytidine diphosphate (CDP) carrier
•Lipid Anabolism - lipid synthesis is known as lipogenesis
•
Øglycerol is
synthesized from dihydroxyacetone phosphate (an intermediate product of glycolysis)
Ø
Ømost lipids, including nonessential fatty
acid chains and steroids, begin with acetyl-CoA
Ø
Ølipogenesis can use almost any organic
substrate because lipids, amino acids, and carbohydrates can be converted to
acetyl-CoA
Ø
Ønot every fatty acid chain that can be broken
down can be built; thus, fatty acids that cannot be built must be obtained in
the diet and are called essential fatty
acids (e.g. linoleic acid and linolenic acid
are essential fatty acids)
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